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Vascular Surgery
 

Osler - Weber - Rendu Disease

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Home > Vascular Surgery > vascular Treatments Available > Osler-Weber-Rendu Disease

Overview

Osler-Weber-Rendu syndrome


Osler-Weber-Rendu syndrome is an inherited disorder of the blood vessels, which can cause excessive bleeding. The syndrome is also called hereditary hemorrhagic telangiectasia, or HHT.


Other Name

Osler Weber Rendu Disease Treatment offers info on Osler Weber Rendu Disease India
[ Hereditary hemorrhagic telangiectasia ]


Causes, incidence, and risk factors

Osler-Weber-Rendu syndrome is inherited as an autosomal dominant trait. The condition can affect males or females of any ethnic or racial group.

Children with this syndrome develop red or reddish-purple collections of abnormal blood vessels called telangiectases.

The syndrome is genetic, which means it results from a broken or missing gene. Scientists have identified some of the genes involved, but do not know exactly how the gene defects lead to the abnormal blood vessels seen in persons with this syndrome.


Symptoms

Frequent nosebleeds in children may be an early symptom.

Telangiectases may not appear until puberty. They can bleed easily and may be seen on the tongue, lips, nasal mucosa, face, ears, fingertips, nails, whites of the eyes, and skin.

There may be GI bleeding, including loss of blood in stool or dark black stools.

Bleeding into the brain may cause symptoms such as seizures or unexplained, small strokes. Severe bleeding can be deadly.

Some patients only discover that they have this condition when they cough up blood and a chest x-ray shows a spot on the lung called an arteriovenous malformation (AVM). Large or multiple AVMs can cause shortness of breath.

A port wine stain is occasionally present.


Signs and tests

An experienced health care provider can detect telangiectases during a physical examination. There is often a family history of hereditary hemorrhagic telangiectasia.

Other signs include : -

  • Chest x-ray may show a "spot on the lung" (arteriovenous malformation).
  • Echocardiogram may show heart failure.
  • Blood tests may reveal iron deficiency anemia.
  • Special blood gas tests may show decreased levels of oxygen in blood.
  • Endoscopy may show abnormal blood vessels that bleed easily in the throat, bowels, or airways.
  • Hepatomegaly may occur if there are abnormal blood vessels in the liver.
Genetic testing may be available for mutations in the endoglin or ALK1 genes.


Treatment

Surgey is needed to treat bleeding in some areas. Frequent or heavy nosebleeds may be treated with electrocautery or laser surgery.

Endovascular embolization may be needed to treat abnormal blood vessels in the brain and other parts of the body.

Some patients respond to estrogen therapy, which can reduce bleeding episodes. Blood-thinning medications should be avoided. Some patients may need to take antibiotics before having dental work or surgery. Ask your doctor what precautions you should take.

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Expectations (prognosis)

Unless there is life-threatening intracranial hemorrhage, persons with this syndrome can live a completely normal lifespan.


Complications

  • Internal bleeding
  • Heart failure
  • Shortness of breath
  • High blood pressure in the lungs (pulmonary hypertension)


Prevention

Genetic counseling is recommended for prospective parents with a family history of hereditary hemorrhagic telangiectasia. Certain types of strokes and heart failure can be prevented with medical treatments.




The list of of Vascular Surgery Hospitals in India is as follows : -


Apollo Hospitals Bangalore Apollo Hospitals, Bangalore, India
Apollo Hospital Chennai Apollo Hospital, Chennai, India
Apollo Hospitals Hyderabad Apollo Hospitals, Hyderabad, India
Apollo Hospitals Delhi Indraprastha Apollo Hospital, Delhi, India
Apollo Hospitals Kolkata Apollo Gleneagles Hospital, Kolkata, India
Apollo Hospital, Goa, India Apollo Hospital, Goa, India
Wockhardt Hospital Bangalore India Wockhardt Hospital, Bangalore India
Wockhardt Hospital hyderabad, India Wockhardt Hospital, hyderabad, India
Wockhardt Hospital Mumbai, India Wockhardt Hospital, Mumbai, India
Fortis Hospital, Delhi, India Fortis Hospital, Delhi, India
Fortis Hospital Mohali, India Fortis Hospital, Mohali, India
Fortis Hospital Noida, India Fortis Hospital, Noida, India
Escorts Heart Institute Hospital, Delhi, India Escorts Heart Institute Hospital, Delhi, India
Manipal Hospital, Bangalore, India Manipal Hospital, Bangalore, India
MIOT Hospital, Chennai, India MIOT Hospital, Chennai, India
Narayana Hrudayalaya Heart Hospital, Bangalore, India Narayana Hrudayalaya Heart Hospital, Bangalore, India
Artemis Hospital, Gurgaon ( Delhi ) , India Artemis Hospital, Gurgaon ( Delhi ) , India
Max Devki Devi Heart and Vascular  hospital,  Delhi, India Max Devki Devi Heart and Vascular hospital, Delhi, India
Max Super Specialty hospital,  Delhi, India Max Super Specialty hospital, Delhi, India
BGS Global Hospital Bangalore, India BGS Global Hospital, Bangalore, India
BGS Global Hospital Chennai, India BGS Global Hospital, Chennai, India
BGS Global Hospital Hyderabad, India BGS Global Hospital, Hyderabad, India


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