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Motor Neuron Disease Treatment

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Overview

Motor Neurone Disease - Stem Cell Therapy India


Motor neurone disease often begins with weakness of the muscles of the hands or feet. It eventually leads to generalised paralysis. People with motor neurone disease need help with daily activities and have a life expectancy of three to five years after their diagnosis.


A variety of physical effects

The physical effects of motor neurone disease (MND) can include : -


  • Weakness or muscle wasting - this is often first noticed in the hands or feet
  • Difficulty swallowing or slurred speech
  • Muscle twitching
  • Cramps
  • Emotional instability, depression
  • Fatigue, pain.



What are the types of motor neuron disease?

  • Amyotrophic Lateral Sclerosis (ALS)
  • Progressive Muscular Atrophy (PMA)
  • Spinal Muscular Atrophy (SMA)
  • Progressive Bulbar Palsy (PBP)
  • Primary Lateral Sclerosis (PLS)



Causes are unknown

The causes of MND are unknown but worldwide research includes studies on : -


  • Viruses, toxins, genetic factors and immune factors
  • Nerve growth factors and chemicals which control nerve cells and allow them to communicate with each other
  • Growth, repair and ageing of motor neurones.


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Effects of motor neurone disease

People who have MND will have : -


  • A potential to develop generalised paralysis
  • Loss of speech and difficulty swallowing
  • A dependence on others for all aspects of day-to-day activity
  • An average life expectancy of 3 to 5 years after diagnosis.


Needs arising from motor neurone disease


As MND progresses there will be : -


  • Increasing pressure on carers as the physical needs of the person with MND change
  • Escalating need for assistance for the person with MND and their support network
  • Emotional pressures associated with a worsening disability - this includes the stress of being cared for.



There is no cure for motor neurone disease


The drug Rilutek (riluzole) has been demonstrated in clinical trials to show a modest extension of life expectancy, and works best in conjunction with support from a multi-disciplinary team of health professionals. Rilutek is available on the Pharmaceutical Benefits Scheme.

Costly and unproven therapies are sometimes recommended by well-meaning people. People should seek professional advice before embarking on unproven therapies.


Coping with the physical and emotional effects

The Motor Neurone Disease Association can help people to cope with the physical and emotional effects of the diagnosis by providing : -


  • Information about MND : - this includes information about experiences that other people have found helpful
  • Home visits : - including visits by volunteers
  • Referral to service providers like attendant carers, nurses, speech therapists, occupational therapists and physiotherapists
  • Equipment loan service or referral to other agencies for equipment
  • Regular telephone support.

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Stem Cell Therapy in India

Stem cells are the master cells of the human body. They can divide to produce copies of themselves and many other types of cell. They are found in various parts of the human body at every stage of development from embryo to adult.

Because stem cells are so versatile, they could potentially be used to repair and replace damaged human tissue. The purpose of experimental stem cell therapy is to offer potential benefits of stem cells, which may be : -

  • To slow down or stop further deterioration caused by the disease
  • To see if stem cells can reverse the effects of the disease



This procedure is considered experimental as it is being tested in clinical research studies, and is not yet available as a standard medical treatment.

The stem cells used in our experimental therapy are Mesenchymal stem cells, which are derived from your own bone marrow. These are multipotent stem cells that can transform into a variety of cell types, and thereby help in regeneration and repair of the diseased tissues.

Motor Neuron Disease Stem Cell Treatment in India


Motor Neuron disease is one of the progressive degenerative neurological disorders having no effective treatment. It dramatically reduces the life span and the quality of life of the patient. Hence the ideal curative treatment in these cases would be the replacement of degenerated or lost cells. The transplanted Adult mesenchymal stem cells have the potential to differentiate into functional neural cell types, thereby facilitating a possible cure.



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